Low responsiveness of synovial and peripheral blood lymphocytes stimulated by either PHA-P or CON-A in patients with chronic rheumatoid arthritis.

نویسندگان

  • S Yamana
  • H Matsueda
  • H Ezawa
  • S Miyake
  • S Katsuyama
  • T Ofuji
چکیده

Lymphocytes were highly purified from synovial fluid and peripheral blood of 10 rheumatoid arthritis patients and assessed for responsiveness to PHA-P and Con-A. In all cases, both synovial and blood lymphocytes showed a marked reduction in response to these mitogens compared with normal blood lymphocytes. The factors responsible for this low T cell responsiveness are discussed.

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عنوان ژورنال:
  • Acta medica Okayama

دوره 32 6  شماره 

صفحات  -

تاریخ انتشار 1978